in vivo skin analysis


The gen2-SCA is a highly sensitive confocal Raman system for in vivo skin analysis.

  • Determine molecular concentration profiles from the skin surface into the dermis, in seconds to minutes, with high spatial resolution. 
  • Obtain information about the concentration and distribution of amino acids, sweat constituents, lipids, proteins, water, and topically applied materials.
  • Study penetration and transdermal delivery of topically applied materials.

Examples of applications are:

  • Water concentration profiles from skin surface to dermis in minutes 
  • Determination of Natural Moisturizing Factor concentration in the stratum corneum
  • Studies of the penetration of topically applied materials
  • Optimization of formulations for actives delivery


Watch this video to learn about the operation of the gen2-SCA and to see it in action!


The gen2-SCA has been custom-designed for rapid, non-invasive data collection from the skin, including the skin of the scalp and the axilla.

Data are analyzed in real-time. The instrument control software RiverICon calculates and shows molecular concentration profiles during data collection. SkinTools-software is available for comprehensive off-line data-analysis

The gen2-SCA uses red and near-infrared laser light and complies with international standards for safe laser light exposure of the skin.


System Installation
gen2-SCA installations are carried out by trained service personnel, authorized by RiverD, who will also teach basic instrument operation and maintenance.

Operator Training
Two-day comprehensive operator training courses are organized 3 times per year at the RiverD-offices in Rotterdam, the Netherlands. For further information, contact RiverD or one of our local distributors. Also see 'Downloads & publications', the section below, for further information on the training course.

Services & Support
RiverD offers a range of services aimed at optimizing your gen2-SCA experience.

  • Remote Instrument Health Monitoring
  • Preferred access to spare parts
  • Study design / data analysis support

Downloads & publications

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Integral Corporation

Shin Meguro Tokyu Bldg. 11F,
2-25-2, Kami-Osaki, Shinagawa-ku, Tokyo JAPAN 141-0021
Tel: +81-3-6417-0810
Fax: +81-3-6417-0853

Contact: Mr. Hiroshi Suzuki



Beijing Jinhongfan trading Co., Ltd

Room 306, Fortune Building, 2# Building, Fuhai Center
No.17 Daliushu Road, Haidian District, Beijing 100081, China
Tel: +86-10-62186640
Fax: +86-10-62182326

Contact: Mr. Liu Wei


True Systems Co.,Ltd.,

D-603, Bundang Techno Park,
Yatap-dong, Bundang-gu, Seongnam-si, Gyunggi-do,
Korea (463-760)
Tel: +82-31-712-8031
Fax: +82-31-712-8041

Contact: Mr. Jong Hyuk Jeon

Clinical research organisations


Ellead Co., Ltd

Shin Meguro Tokyu Bldg. 11F,
325, Hwangsaeul-ro, Bundang-gu,
Seongnam-si, Gyeonggi-do, Korea
Tel: +82-31-709-9030
Fax: +82-31-703-9071


proDERM GmbH

Institut für Angewandte Dermatologische Forschung
Kiebitzweg 2, 22869 Schenefeld/Hamburg
Tel: (040) 839 358-99


United States

Biometrix Inc.

2419 Ocean Avenue
San Francisco, CA 94127
Tel: 415-333-0522
Fax: 415-333-0532


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Contact us

RiverD International B.V.
Marconistraat 16, Europoint IV
3029 AK, Rotterdam
The Netherlands

+31 (0)10 704 48 41

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